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Why Some Diseases Only Traveled One Direction

50 videos recommended on HN
YouTube
11 HN users recommended this explainer9 months2015–2024 score 10
Years with an HN recommendation, 2007–2026

HN commenters point to it as a clear, short explanation of one-directional disease spread and the core argument of Guns, Germs, and Steel.

CGP Grey explains why European diseases devastated the Americas while few deadly diseases traveled the other way. He ties it to livestock domestication, dense cities, and the ideas of Guns, Germs and Steel.

“I think CGP Grey does a great job at communicating the actual meat of Guns, Germs, and Steel here” (HN, 2019)

2 strong recommendations · 9 recommendations · 5 citations · Explainers

16 Hacker News comments

From the HN archive; up to 20 kept per video, favoring different commenters. Recommendations first.

@vinceguidry Nov 2015 Strongly recommends
on HN thread The New China Syndrome: American business meets its new master
Read more
> So any theory of "geographical stunting" would need to explain what changed in the geography after 1492. What changed was technology. Once you have ships going back and forth across the Atlantic, everything changes. Europeans introduced cows, sheep, pigs, chickens. The New World's only domesticable native animal is the llama, which is the main reason why civilizations sprung up in Central and the northern parts of South America, that's where llamas were. Now, to the Europeans, with vastly superior farming technology, the Caribbean and North America were veritable cornucopias of geopolitical possibility. Islands sheltered plantations. Europe could project real power only very closely to the shore, where the big naval guns could reach. The reason was supply. To maintain a group of soldiers requires not just food but adequate clothing, weapons, ammunition, and horses to carry all of that. It took over a century of growth for a colony to get to the point to where it could maintain and supply an army for deeper treks inland. By that time the colonies would have been deeply entrenched in native political systems. Because the warships protecting your colony could only hang around for so long, colonies were quite vulnerable to native military action, or even just having them hang around outside the settlement and killing whoever goes outside, say, to chop wood. It made sense for settlers to be nice to the locals, at least at first. CGPGrey just put out a fantastic video comparing t
Compares how geography and domestication shaped the New World and Old World.
@bigmattystyles Oct 2022 Strongly recommends
on HN thread How the ‘black death’ left its genetic mark on future generations
Expanding on this, CGP Grey had this amazing video ( [this video] ) of why European diseases in the Americas were so bad on the people that were already here when the two worlds met but you hardly heard of Europeans getting any super contagious illness from the people living in the Americas. Meaning European genomes had some adaptations (as well as antibodies?) from dense and unsanitary living, as well as animal farming in European prior to contact whereas that type of living setup was rarer in the Americas.
Explains why European diseases ravaged the Americas but not the reverse.
@valarauca1 Oct 2016 Recommends
on HN thread Barack Obama: America Will Take the Giant Leap to Mars
>Indians had no trouble crisscrossing America Well yeah there weren't any human infectious illness where... there aren't any humans. This video explains the history of man kind's infectious illness very well [this video]
Explains the history of human infectious illness.
@partycoder Jun 2017 Recommends
on HN thread Native Intelligence (2005)
I recommend the following video by CGP Grey, largely based on the book "Guns, Germs and Steel" by Jared Diamond: [this video] Now, history doesn't give a lot of merit to natives. The largest battle in the Americas, the siege of the Aztec capital Tenochtitlan, was won with the help of 80,000 to 200,000 Tlaxcalan natives, which amounted for 99% of the infantry used.
Video summary of Guns, Germs and Steel ideas on disease and conquest.
@squirrelicus Jan 2019 Recommends
on HN thread Germs and ancient migrations help explain our world of 'haves' and 'have nots'
I remember being struck by his anecdotes of Papua New Guineans seeming just as smart as anyone else as supposed evidence of... What exactly? I don't think Neil Diamond is wrong but it's kind of baby's first reading on the differences between groups in the world. I think CGP Grey does a great job at communicating the actual meat of Guns, Germs, and Steel here [this video]
Communicates the core argument of Guns, Germs, and Steel well.
@majewsky Feb 2021 Recommends
on HN thread Coronavirus Mutants Are Spreading Fast
Read more
Epidemics are a relatively new phenomenon as far as human evolution is concerned. Within a purely human set of hosts, germs don't feel evolutionary pressure to become more deadly. If anything, it's advantageous for a germ to be less deadly. The most successful viruses are the common cold viruses, not SARS or Ebola. Epidemics only really became a thing once we started domesticating animals and therefore being around live animals for prolonged periods of time. This allowed germs originally adapted to these animals the opportunity to jump over to human hosts, for which they may be more dangerous than for the original host animal. For more details on this point, I can recommend this video on why the native Americans were killed by diseases imported by the European conquerors, but the conquerors didn't bring any deadly diseases back to Europe: [this video]
Explains why Europeans' diseases devastated Native Americans but not vice versa.
@seph-reed Oct 2021 Recommends
on HN thread Evidence for European presence in the Americas in AD 1021
CPG Grey has a great video on this exact subject: [this video] In short, you need cities to develop these types of viruses. Cities where the virus can just keep killing, without ever hitting a dead end.
Explains that cities let viruses persist and develop.
@akerl_ Aug 2023 Recommends
on HN thread FDA Approves First Oral Treatment for Postpartum Depression
[this video] is a good watch here, if you're curious why Europeans didn't catch reciprocal plagues when traveling to the Americas. Spoiler: it's what the adjacent comment said, the Americas didn't have the factors for plagues.
Explains why Europeans caught no reciprocal plagues in the Americas.

Citations, criticism and jokes

@jack9 Apr 2016 Cites it
on HN thread School Is to Submit
> the primary reason for greater productivity of European settlers compared to native inhabitants of Americas would be culture More likely, simple domestication. The "culture" of cities are born of the variety of euro-domestication. Horses, Sheep, etc. ( [this video] )
@slavik81 Mar 2020 Cites it
on HN thread Time to Ban Wet Markets
Read more
It's not the same. Live ocean creatures are isolated from each other. They're stored in water-tight containers by necessity. By contrast, live land animals are stored in cages and often stacked on top of each other. Vox has a video explaining "Why new diseases keep appearing in China" [1]. They include footage of Chinese wet markets around the 2:00 mark. I think they make an excellent case for strictly regulating, or even outright banning wet markets. Long ago, Europe had the same problem. The cities were full of wet markets, and were basically the perfect conditions for creating new plagues. There's a nice CGP Grey video on this, "Americapox: The Missing Plague" [2]. [1]: [link] [2]: [this video]
@JumpCrisscross Jul 2024 Cites it
on HN thread CO poultry workers test positive for bird flu after outbreak at egg facility
> Some of the scariest viruses of the 20th/21st century emerged in large-scale farming operations Before that they emerged from small-scale farming. “Whooping cough comes from pigs as does flu as well as from birds; our friend the cow alone is responsible for measles, tuberculosis and smallpox” [1]. Proximity, to humans and animals, drives disease. [1] [this video]

Video list and Hacker News comment labels from HackerTube (prompted by @karpathy), released under ODC-By 1.0, built on the open-index/hacker-news archive. Hacker News data is provided by Y Combinator; comments remain the work of their authors. Video titles, channel names and thumbnails belong to their creators and are shown via YouTube. HackerTube Watch is an unofficial edition. Data export of 2026-10-31.

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