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How the Krebs cycle powers life and death – with Nick Lane

17 videos recommended on HN
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2 HN users recommended this lecture2 months2022–2026 score 2
Years with an HN recommendation, 2007–2026

HN commenters point to Nick Lane as an excellent science communicator whose talks on mitochondria and the chemistry of life are worth watching.

Biochemist Nick Lane gives a Royal Institution lecture arguing that the Krebs cycle is central to what makes cells alive, not just genetic information. He draws on the themes of his book Transformer to link metabolism to the origin of life, death, and aging.

“excellent science communicator; you can watch some of his talks online.” (HN, 2025)

2 recommendations · 3 citations · Lectures

5 Hacker News comments

From the HN archive; up to 20 kept per video, favoring different commenters. Recommendations first.

@wfn May 2025 Recommends
on HN thread Transformer: The Deep Chemistry of Life and Death
Read more
I've read part of Nick Lane's other book, The Vital Question , cannot comment on this new one; TL;DR competent biochemist (from complete amateur standpoint at any rate), excellent science communicator; you can watch some of his talks online. e.g. the one linked on this new book's page is good: [this video] He's really fascinated by the overall transformation process of inorganic matter -> organic matter, a sort of scientific fixation - which is always enjoyable when it's done by a competent scientist - and it's really captivating stuff. (The fact I haven't finished his previous book has nothing to do with the book material itself, if anything it really captivated me; it's just my not-amazing new habit of not finishing books...)
Good talk from an excellent science communicator on the chemistry of life.

Citations, criticism and jokes

@zoogeny Oct 2022 Cites it
on HN thread Intelligence Beyond the Brain [video]
Nick Lane is another interesting person who is exploring alternative ideas related to cells. Although their work is not exactly the same, I find it interesting to ponder these ideas together. Some videos: 1. Krebs cycle and Transformers at Royal Institute: [this video] 2. A wide-ranging discussion on Lex Friedman podcast: [link]
Nick Lane on the Krebs cycle, relevant to ideas about cells.
@diroussel Jun 2024 Cites it
on HN thread Can ketones enhance cognitive function and protect brain networks?
Interestingly I was just watching talk from Nick Lane, presented at the Royal Institution about mitochondria and respiration. What is amazing to me is that respiration isn’t just burning glucose to make ATP, it also makes many other essential building blocks needed for health cells. [this video]
Talk on mitochondria and respiration beyond making ATP.
@morphle Apr 2026 Cites it
on HN thread Biology is a Burrito: A text- and visual-based journey through a living cell
The research into the origen of life looks at bottom up fundamentals (how they work) of all cells since the solar system was formed. You could start with the slides in this lecture and read the underlying papers and all the references in all those papers. You probably can find these references also in all the books he wrote. [this video] Maybe an educational text for the laymen has summarised this recently but I'm not aware of one. Most Biology from your school days have been rewritten.
Lecture slides pointing to underlying origin-of-life research papers.

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