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I Genetically Engineered *MYSELF* to Fix Lactose Intolerance

10 videos recommended on HN
YouTube
8 HN users recommended this demo7 months2018–2026 score 8
Years with an HN recommendation, 2007–2026

HN keeps citing it as the standard example of accessible DIY gene engineering and self-experimentation, in threads on gene therapy, CRISPR and biohacking.

The Thought Emporium's host describes making and taking a DIY gene therapy to treat his own lactose intolerance. It uses an AAV virus to deliver DNA coding for the lactose-digesting enzyme, made with biohacker Gabriel Licina's help.

“The rest of the channel is pure biohacking gold.” (HN, 2021)

2 strong recommendations · 6 recommendations · 12 citations · Demos

20 Hacker News comments

From the HN archive; up to 20 kept per video, favoring different commenters. Recommendations first.

@Confiks Jul 2021 Strongly recommends
on HN thread What if biohackers injected themselves with mRNA?
You mean like the guy who in 2018 claimed to have cured himself of lactose intolerance for a while by ingesting a gene-modifying Adenolike virus? [1] No fancy lipid-bubble-riding mRNA necessary. The rest of the channel is pure biohacking gold. The yeast spider silk video is much recommended. [1] [this video]
Channel full of biohacking, with a self-cured lactose intolerance story
@mrtksn Jul 2023 Strongly recommends
on HN thread Growing Rat Neurons to Play Video Games [video]
Read more
Interesting is understatement, it's a channel which is one of the closer ones to hard science on the hard science - pop science spectrum and still having more than a million subscribers. Some outstanding videos IMHO: The channel owner applies himself a gene therapy to fix his lactose intolerance. [this video] How exactly the Covid Tests work: [link] Growing Human Neurons Connected to a Computer [link] Especially the Covid test video was eye opening against the conspiracy theorist propaganda during the pandemic because knowing how tests actually work on practical level makes you see through the claims effort free.
Outstanding video from a near-hard-science channel
@thatcherc Jan 2020 Recommends
on HN thread FDA approves first US phage therapy trial (2019)
I'm pretty sure this is the video that describes the whole process, in case you want to hear more about it. (Haven't watched it myself but it's been on my to-watch list for while) Comes from a YouTube channel called Though Emporium: [this video]
Describes the whole process of the self-treatment
@DecoPerson Mar 2021 Recommends
on HN thread Moderna mRNA sequence released to GitHub [pdf]
Check out this video by The Thought Emporium to see how far we’ve come in these matters: [this video] This should hopefully provide you with some useful perspective.
Perspective on how far DIY biology has come
@pas Jul 2021 Recommends
on HN thread Open Insulin Foundation
Read more
If I understand correctly the problem is that if you go to one of their labs they'll cook you a batch in no time (we know the genes, you can order a plasmid that has all the bells and whistles needed to get it made in yeast), but it'd be illegal for many reasons. (They can't sell it without FDA approval for one, they'd need an approved factory for that, and they are infringing on patents.) They obviously can't advertise this, but in videos they almost literally spell this out. So they do this strange outreach instead, with no clear steps in sight. Plus as others mentioned it's easy to buy insulin. ($25 at Walmart.) About how easy it is to make recombinant insulin I recommend this channel: [this video]
Channel showing how easy recombinant insulin is to make
@bschne Jan 2022 Recommends
on HN thread International Linguistics Olympiad – Sample Problems
What got me started was probably this from "The Thought Emporium", and other videos on his channel: [this video] (obvious don't try this at home disclaimer). What I'm reading right now is "Molecular Biology of the Cell" — it's a dense textbook and I'm taking my time, so only about two chapters in, but I love how it focuses on a lot of fundamental principles and occasionally points out astonishing facts. There's also this series which might be a nice, casual primer: [link] James Somers also lists some other books in his post I linked to above, might be worth checking out.
Video that got the commenter into molecular biology

Citations, criticism and jokes

@bicubic Dec 2018 Cites it
on HN thread Deformities Alarm Scientists Racing to Rewrite Animal DNA
Eh. With gene drives we already have the technology to selectively target or not target particular ethnic groups. Bio weapons are amongst the top threats we pose to ourselves as a species. There’s a youtube series by a guy who made a virus to cure himself of lactose intolerance via gene therapy, that was pretty eye opening. To go from what he did to making a targeted bioweapon is not that much of a leap. [this video]
Example showing how accessible gene engineering is
@jcims Feb 2021 Cites it
on HN thread Making Vaccine
The capability of independent ‘biohacking’ researchers is increasing at an astronomical rate. Justin from The Thought Emporium created a fairly durable treatment for his own lactose intolerance [this video]
Independent researcher treated his own lactose intolerance
@modeless Nov 2021 Cites it
on HN thread Probiotic that produces lactase enzymes directly in gut
The lorem ipsum on the "journal" page does not inspire confidence. But I definitely believe that the idea is feasible. There's that guy who genetically engineered himself to produce lactose[1] and it worked, and this seems like a less risky way to do it. I'd love for a real product along these lines to come out. Would it even be legal to sell it though? [1] [this video]
Precedent for engineering oneself to digest lactose
@noveltyaccount Feb 2022 Cites it
on HN thread Woman appears cured of HIV after umbilical-cord blood transplant
The video: [this video] - and it did wear off after several months, he discusses it in follow up videos. Speaking for myself, taking a lactose CRISPR treatment twice a year sounds pretty nice compared to avoiding dairy and/or taking lactase with many meals.
Treatment wore off after several months
@haxiomic Oct 2023 Cites it
on HN thread John Carmack on AI
It takes less than you think, you can order sequences online Here's a youtuber designing a custom virus to cure his lactose intolerance [this video]
Youtuber designed a custom virus to cure lactose intolerance
@derefr May 2024 Cites it
on HN thread Deaf girl is cured in world first gene therapy trial
Read more
> I agree with that evaluation, but I also think mavericks should be allowed to try curing their own colorblindness (assuming they had informed consent and paid for the therapy themselves). I mean, what's stopping you? This guy cured his own lactose intolerance: [this video] But I'm guessing — in part because you say "paid for the therapy" — that you don't really mean "should be allowed to cure their own colorblindness"; but rather "should be allowed to buy a colorblindness treatment from a vendor of such" or maybe "should be allowed to request a prescription of a colorblindness treatment from a doctor who acquires it from a vendor of such." And you're already also allowed to do that — in theory. The FDA doesn't care about people buying medical treatments. It cares about companies selling them. Because companies are profit-focused, and the quickest way to money in medicine is to lie. For you to be able to get what you want, there'd have to be an intermediate category that stops just shy of the current "FDA-approved medical therapy" category. For a treatment to qualify for this category, it would still have to pass both safety and efficacy studies. The only thing that would be different, is that the FDA wouldn't weigh the safety vs. the efficacy of the treatment at the end; but instead just put an absolute minimum threshold on both safety and efficacy, and leave the prescriber to determine whether the safety risk outweighs the efficacy. But think about that word "prescriber." This
YouTuber engineered himself to cure lactose intolerance
@FL33TW00D Dec 2025 Cites it
on HN thread CRISPR fungus: Protein-packed, sustainable, and tastes like meat
The paternalistic state does not allow you autonomy over your own body. e.g the amount of backlash thought emporium got when he genetically engineered himself to remove lactose intolerance: [this video] Risky, but it's his body!
Self-experimentation with genetic engineering and the backlash it drew
@dlcarrier Dec 2025 Cites it
on HN thread Scientists Edited Genes Inside a Living Person for First Time, Saved His Life
There was a guy on YouTube who genetically engineered himself to gain lactose tolerance. ( [this video] ) It lasted for around a year and a half ( [link] ) before the effect mostly wore off. He took it orally, so it only affected his intestinal lining, and I presume it didn't effect enough stem cells to get a permanent effect, but it would still be usable as something taken annually, which is still far less often than any medication.
Oral gene therapy gave lactose tolerance for about a year and a half

Video list and Hacker News comment labels from HackerTube (prompted by @karpathy), released under ODC-By 1.0, built on the open-index/hacker-news archive. Hacker News data is provided by Y Combinator; comments remain the work of their authors. Video titles, channel names and thumbnails belong to their creators and are shown via YouTube. HackerTube Watch is an unofficial edition. Data export of 2026-10-31.

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