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Frame from The Evolution of Bacteria on a “Mega-Plate” Petri Dish (Kishony Lab) Plays via YouTube's privacy-enhanced embed

The Evolution of Bacteria on a “Mega-Plate” Petri Dish (Kishony Lab)

Harvard Medical School
Demos
YouTube
6 HN users recommended this demo5 months2016–2026 score 6
Years with an HN recommendation, 2007–2026

HN links it as a visually striking demonstration of evolution and antibiotic resistance happening in days.

A two-minute time-lapse from the Kishony Lab showing bacteria spreading across a giant petri dish with increasing antibiotic doses, evolving resistance as they go.

“the mega-plate video is an unbelievably good demonstration of bacterial evolution” (HN, 2019)

2 strong recommendations · 4 recommendations · 10 citations · Demos

16 Hacker News comments

From the HN archive; up to 20 kept per video, favoring different commenters. Recommendations first.

@lossolo Sep 2016 Strongly recommends
on HN thread The Age of the Superbug Is Here
This is an amazing video[1] from Harvard Medical School released couple of days ago showing evolution of bacteria that evolve in 10 days to become resistant to antibiotics. [1] [this video]
Bacteria become antibiotic resistant in ten days
@robocat Jul 2019 Strongly recommends
on HN thread Bladder cancer 'attacked and killed by common cold virus'
> Why do you think the strongest of the strong bacteria are found in hospitals? I presume you mean strong against antibiotics and sterilisation. The evolved bacteria are likely weaker along other dimensions (that are less important for survival in a hospital setting). Some evolution is compromises, improving X has cost Y. Aside: the mega-plate video is an unbelievably good demonstration of bacterial evolution: [this video] especially note the tree at the end showing how many different mutations evolved.
Unbelievably good demonstration of bacterial evolution
@Retric Sep 2016 Recommends
on HN thread Videos of Evolution in Action
The video shows mutations in real time as bacteria grow or fail to grow in various places. [this video] It's more a demonstration than experiment, but visually it's just really striking.
Visually striking real-time bacterial mutation demo
@sengork Jan 2017 Recommends
on HN thread How to Avoid a Post-Antibiotic World
For those that would like to visualise how the bacteria vs anitbiotics evolve in an experiment over 11 days, have a look at this video from Harvard: [this video]
Visualizes bacteria evolving against antibiotics over 11 days
@ramgorur Mar 2018 Recommends
on HN thread The man who bottled evolution
Harvard medical school did a similar experiment on fast evolution of bacterial resistance to antibiotics on a petri-dish. It also clearly shows the lineage of evolution. Very interesting. [this video]
Fast bacterial resistance evolution with lineage shown
@idiocrat Jan 2023 Recommends
on HN thread It's 2023 and I still have to touch a piss soaked door handle to exit a bathroom
Strengthens your immune system. Without exposure (playing in mud, touching other people), we are only weaker. Bio life is really complicated. Sterilization works well only to a certain degree, before becoming damaging, e.g. causing resistance. Somewhat related, here is an interesting visualization of bacteria developing resistance to antibiotics. [this video]
Visualization of bacteria developing antibiotic resistance

Citations, criticism and jokes

@lmilcin Jan 2019 Cites it
on HN thread Pliocene and Eocene provide best analogs for near-future climates
Read more
It is absolutely nowhere near evolutionary adaptive capacity. Life will not end and the world will still be there. Life's evolutionary adaptive capacity is stagerring! Just take a look at the experiment where it barely stretches muscles: [this video] What I understand they mean is "Life as we know it" defined as large animals and familiar plants roughly in places where we are used to seeing them. We are looking at life with our antropocentric point of view and we basically want familiar stuff to stay the same and we don't want unfamiliar stuff to show up. We don't want things to change and that's why potential large shift in how life presents itself may be caulled as "end of the world" event, but it is not. Life doesn't care whether oceans are clean or polluted, hot or cold. It WILL adapt some way or another even if all crustaceans and fish will die because they can't adapt quickly enough to lowering pH. We should care not because life is at danger but because we are at danger. Life as we know it is a machine that supports us, let's us grow food and provides air and water and soil and climate that we need. Humans will survive for sure in one way or another even if the temperature rises by 20 degrees but what kind of life will it be and how much suffering for those that can't deal with it?
Shows life's adaptive capacity
@HPsquared Mar 2021 Cites it
on HN thread Moore's Law for Everything
Technological innovation is a balance between diminishing returns (ever-smaller niches getting filled, ever-increasing complexity) and the occasional breakthrough which spawns further development. The visual metaphor of bacteria developing antibiotic resistance in ever-greater levels of the antibiotic, springs to mind: [this video]
Visual metaphor for diminishing returns in innovation
@woopwoop Jun 2021 Cites it
on HN thread History as Weather
Non-obvious is necessary to avoid appending "and also the sun rises in the east and sets in the west every day" to every prediction to get it to satisfy the other three. That a fact is observational does not make it non-scientific. I have no problem calling a description of a human cell science. I'd also add that you absolutely do not need 500 years to verify natural selection, see e.g. this video: [this video]
Shows natural selection verified without centuries
@_vertigo Aug 2021 Cites it
on HN thread Vaccination blunts, but does not defeat Delta
Read more
Honest question here, do vaccines actually reduce the chance for covid to mutate? Spitballing, I would expect a vaccine to decrease the number of total mutations that can occur but also simultaneously increase the selective pressure on the virus, increasing the chance that any mutations that improve the virus’ ability to resist the vaccine become dominant. To make an analogy, does spraying every surface in a hospital with an antibacterial solution result in no bacteria or just make it more likely to see resistant bacteria? I’d guess it’s a function of how potent the solution was and how well every last surface was coated. If you start with a 10% solution, don’t achieve full coverage and keep ramping up slowly perhaps we’ll just see something like this: [this video] Agree with the rest of your post though.
Resistance emerging under rising selective pressure
@jasode Dec 2021 Cites it
on HN thread DNA seen through the eyes of a coder
>What are the tests? Tests == adaptation to the environment E.g. short 2 minute video showing how bacteria evolves with random mutations to produce resistance to antibiotics: [this video] Likewise at a macro scale, if Earth's atmosphere becomes inhospitable because of global nuclear war or a big asteroid collision, then the new "test for life" is adapting to the radioactive dust cloud. Keep mutating across generations until survivors can thrive.
Short demo of bacteria evolving resistance
@taf2 Jul 2022 Cites it
on HN thread No antibiotics worked, so this woman turned to phage scientists
Really I feel like this has been a hot topic for at least 15 years.. for example 5 years ago this [this video] was on hacker news and got a lot of discussion as I recall… Ok maybe you are right my search yielded few posts that got any traction - so maybe it was just me sharing with people I know!
@robocat Feb 2023 Cites it
on HN thread A tiny genetic change inflicts old age on young kids
Read more
Aging is one side effect of a major internal system that counteracts cancers. Most of our cells are preprogrammed to die after a certain number of replications. This is one of many systems that counteract normal genetic mutations - which can cause cancers and other side effects. By definition a cancer has to reproduce and one way of defeating cancers is for cells to die (or be killed) once they reach a number of cell reproductions. Think of a binary tree where the tree depth is the number of cell reproductions, and telomere length controls tree depth. Each time a cell reproduces it risks mutations. Stem cells are the progenitor branches, and stem cells maintain “cleaner” copies of DNA, which then become normal cells. Normal cells then reproduce a number of times before they kill themselves. We have evolved this system because it balances the shorter term harms of cancer (high cost preventing reproduction), and senescence (lower cost after reproduction). There can be no “cure” for cancer, or aging. The cure would for cancer would require some way to either cause perfect cell reproduction, or to remove (or correct) all cells with imperfect reproductions. The “cure” for aging would require a cure for cancer. If I were to invest in something myself, it would be brain transplant, since brain cancers are rare, and dealing with organ rejection seems doable, and the issue of nerve reconnection seems solvable. The main problem is finding spare bodies, which can be unethically solved f
@MontyCarloHall Jun 2026 Cites it
on HN thread CRISPR Tech Selectively Shreds Cancer Cells, Including "Undruggable" Cancers
>there's no "be a better/stronger cancer and spread more effectively to more hosts" No, but there is "be a better/stronger cancer cell and don't succumb to whatever therapy is killing its neighboring cells." It's exactly akin to how dosing isolated populations of bacteria with antibiotics selects for individual cells that are resistant, which then multiply and dominate [0], just like a tumor. [0] [this video]
Antibiotic selection mirrors tumor therapy resistance

Video list and Hacker News comment labels from HackerTube (prompted by @karpathy), released under ODC-By 1.0, built on the open-index/hacker-news archive. Hacker News data is provided by Y Combinator; comments remain the work of their authors. Video titles, channel names and thumbnails belong to their creators and are shown via YouTube. HackerTube Watch is an unofficial edition. Data export of 2026-10-31.

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